the company

Meletios Therapeutics aims to address the urgent and significant unmet medical need for antiviral treatments for current and emerging viral infections by developing innovative small molecules and defective viral genomes.

This French biotech company was created in April 2020 by a team of high level scientists and experienced biotech managers.

One of our first drug candidate has confirmed its broad-spectrum potential in in vitro and in vivo models on the coronavirus family and influenza H1N1, demonstrating a dual antiviral and anti-inflammatory activity. This molecule will now be developed and tested in order to meet regulatory requirements and enter clinical phase II.

Several drug candidates from Meletios portfolio are currently being tested both in vitro and in vivo and will expand our range of antiviral molecules on different RNA viruses. Some of these molecules have already been tested in the clinic for other human diseases, so they will have the following two main advantages: a well-known safety profile and accelerated development.

Meletios Therapeutics’ goal is to become a global leader in the fight against emerging viral infections by developing innovative broad-spectrum therapeutic solutions.


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As far back as we can remember, there has always been a real concern for human communities about epidemics which have been incredibly devastating in the past. And we are nowadays seeing a speeding up of the phenomenon. We are increasingly interconnected and pushing the boundaries of our environment further and further, yielding unknown viruses to come out into the open.

There is thus a real need to anticipate the emergence of new viruses that could lead to globalized epidemics such as COVID-19.


To tackle future emerging viruses, every effort must be made to channel epidemics. Vaccines and treatments are two complementary therapeutic strategies.

Vaccines are an essential preventive tool but have the disadvantages of targeting a virus that must be already (well) known and of being uncertain about possible variants. They can be also time-consuming to implement.

An alternative is therefore needed for patients who are already ill in order to treat their symptoms and to resolve the infection from the start of the epidemic. Depending on their mechanism of action, antiviral drugs can be effective against a wide range of viruses and therefore offert significant hope for limiting the impact of pandemics.

A need for broad-spectrum antivirals to rapidly save patientslives regardless the virus strain causing the pandemic

We are facing an increasing number of pandemic situations

New viruses are to emerge with a lack of overlap between viruses



Vaccines are mostly efficient against one strain only

Implementation in the population takes long

Viral genome are small and evolve rapidly

It is sometimes impossible
to design a vaccine for a virus



The current antiviral armamentarium is not sufficient to face current and future epidemics

Broad spectrum treatment could be used as soon as a viral pandemic is identified

Antivirals will be efficacious against a large panel of viruses


25 years of biotech & pharma experience, strategic and operational positions, Engineer graduated from Ecole Centrale.
MARC SALOMÉ Senior Scientist
Co-founder of Meletios, engineer from ETH Zürich and researcher, extensive experience with various pharma companies on microbial physiology, cholesterol metabolism, co-author of 7 patents.
Co-founder of Meletios, Pharmacist, PhD specialized in microbiology, former director of discovery biology at Stellate therapeutics.
ANNA ELGART Project Manager
Polytechnique & Mines ParisTech Engineer, experience with various healthcare players: hospitals, medical device, research laboratories.
RODRICK MONTJEANDiscovery Project Manager
Ph.D (Paris Descartes University), specialized in Biochemistry, Molecular and Cellular Biology, experience in both preclinical development and elucidation of drug mechanisms of action.
LYDIE BOUSSICAULTDiscovery Project Manager
Ph.D (Pierre and Marie Curie University), specialized in Biochemistry and Cellular Biology, experience in biotech (preclinical project management).
Biotechnologist, specialized in Biomolecular Sciences. CMC specialist with experience in Drug Development on multiple pharmaceutical forms, CDMO/CMO management and Module 3.

Our Board

Patrice Garnier
Patrice Garnier
President and co-founder of Meletios Therapeutics. Originator of 6 start-ups. PhD in quantum physics / nanotechonogy.
Alexandre Mouradian
Alexandre Mouradian
Chairman and Founder of Eurekare, a biotech fund. Chairman of the Spinoza Foundation, a charitable organization set up to promote a deeper understanding of the challenges which our global society faces.
Catherine Martre
Catherine Martre
CEO of Meletios Therapeutics. Leading strategic positions in the pharma industry, commercial operation and market access in Advicenne, a French Biotech company.
Emmanuel de Rivoire
Emmanuel de Rivoire
General Manager of Kinnov Therapeutics, a French Biotech dedicated to addiction. Senior international executive in Pharma industry (Takeda, Nycomed, Roche, GSK, Abbott), he has 30+ years experience in Europe, Middle East/Africa and Asia.
Franck Mouthon
Franck Mouthon
CEO and founder of Theranexus, a French biotech dedicated to rare diseases in Neurology. Franck is also President of the French Biotech companies association.
Gerard Le Fur
Gerard Le Fur
Former CEO of Sanofi-Aventis, and renown pharmacologist. Head of Sanofi’s Research and Development for several years. Member of the French Science Academy.
Stephane Delacote
Stephane Delacote
Founder of Tigres Investissement. He worked in investment banks and is skilled in nonprofit organizations and entrepreneurship. Stephane is an experienced business development professional graduated from Ecole des Mines de Paris.


Felix Rey
Felix Rey
Pr. Felix Rey is leading the Structural Virology Unit at Institut at the Institut Pasteur. His research focus has included the 3D structures of viral polymerases and the study of viral envelope proteins. Felix is a member of the French Sciences Academy.
Marco Vignuzzi
Marco Vignuzzi
Marco Vignuzzi holds a PhD in microbiology and virology. He founded his laboratory at Institut Pasteur Paris in 2008 and joined A*Star-IDLab in Singapore in 2022. He is an expert in virus evolutionary mechanisms and Defective Viral Genomes.
Antoine Danchin
Antoine Danchin
Mathematician and molecular biologist, Pr. Antoine Danchin is a pioneer in synthetic biology. He was the director of the Department Genomes and Genetics at the Institut Pasteur in Paris and is also a member of the French Sciences Academy.
Vincent Maréchal
Vincent Maréchal
Vincent Maréchal is a professor of Virology of Sorbonne Université, INSERM unit director at Saint-Antoine Hospital/APHP. He is also the founder of Obepine network for the epidemiological surveillance of SARS-Cov-2 in wastewater.

meletios’ R&D STRATEGY

We are developing two complementary approaches to combat RNA viruses. Meletios works closely with recognized experts to guide us in each direction.

The first angle is to develop a broad-spectrum antiviral drug by targeting host mechanisms that are hijacked by viruses. In vitro and in vivo proofs of concept were obtained with our small molecules.

The second approach is a disruptive technology from the Institut Pasteur that consists in parasitizing the viral machinery with defective genomes to prevent it from producing new infectious virions.



Small molecules

Host functions hijacked by viruses

– Broad spectrum molecules
– In vitro & vivo proof of concept
– Internal Meletios Development



Defective viral genomes

Parasite of viral machinery

– Disruptive technology
– Originating from a prestigious academic center: The Institut Pasteur


Meletios Pipeline


2 November 2022 – Meletios Therapeutics receives €5.2 million in funding from the European Innovation Council Accelerator for the clinical development of its candidate MLT103
Read our Press Release
2 March 2022 – License agreement with the Institut Pasteur for a new class of antivirals: Interview – Marco Vignuzzi (Institut Pasteur) x Catherine Martre (Meletios Therapeutics)
Watch the interview
Read our Press Release
7 September 2021 – 3 questions to Catherine Martre, CEO of Meletios Therapeutics
Watch the interview
Read our Press Release



The mission is to take charge of the synthesis process and the supply of active ingredients, as well as the formulation and manufacturing of the products in the portfolio, taking into account the regulatory constraints, in order to allow the completion of preclinical studies and the first clinical phases of the products developed by the company in the targeted indications.


Coordination of CMC activities, from the development of the chemical synthesis process, from galenics to industrial scale-up

  • Development of the active ingredient synthesis process with partners.
  • Process development and scale up.
  • Characterization/Analytical Validation API and Drug products.
  • Pre-formulation and formulation studies (outsourced).
  • Batch generation for toxicity studies and GMP batch for clinical studies
  • Follow-up of the production and validation of non-GMP and GMP batches
  • Conduct of CMC regulatory activities related to regulatory files
  • Follow-up/Drafting of scientific, technical and regulatory files (IMPD, eCTD, IND, NDA)
  • Search and evaluation of subcontractors,
  • Coordination of subcontractors involved in pharmaceutical development, in compliance with quality and regulatory standards, deadlines and costs
  • Management of preclinical and clinical logistics
  • Securing the supply of active ingredients

You have a scientific background (Master 2 Industrial Pharmacy / formulation / production processes, Chemical Engineer, PharmD or PhD). You have a solid knowledge of chemistry and galenics (properties of active ingredients, properties of excipients, galenic forms), associated manufacturing processes and regulatory requirements. You have a minimum of 5 years of successful experience related to the missions expected for this position.

You have a taste for challenge and you are motivated to join a young and innovative company. You are autonomous, innovative, have a strong sense of initiative and are attracted by teamwork. You communicate fluently in English, both in writing and orally, and have a sense of priorities and organization.

Permanent contract to be filled immediately. Paris

Contact: Please send your application to

You are interested in joining our team? Do not hesitate to submit your application with a cover letter and resume at!

Please send your application to

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